Development of blister packaging technology for th

Development of drug blister packaging technology in China

the blister packaging of drugs is formed by filling the drugs in the blister formed by vacuum suction (blowing) or molding, using covering materials such as aluminum foil, and sealing with the foaming substrate under certain temperature and time conditions through pressure. Blister packaging of drugs, also known as blister packaging, is one of the main forms of drug packaging, which is suitable for the mechanized packaging of solid preparations such as tablets, capsules, suppositories, pills and so on

the rise of blister packaging in China

as early as the 1930s, blister packaging of drugs first flourished in Europe, and slowly and steadily developed to the world. China introduced medical Blister machinery and equipment in the early 1970s, but aluminum foil and other materials for blister packaging still need to be imported. It was not until 1986 that China began to introduce more advanced foreign materials for blister packaging. 3. Intermittently lubricate the moving parts of the compression testing machine; The "PTP" aluminum foil printing and coating production line of Japan Toyo Aluminum Co., Ltd. was first introduced by the Guangzhou Pharmaceutical Administration of the State Pharmaceutical Administration, and then China Pharmaceutical Industry Corporation and Lianyungang pharmaceutical company jointly introduced the "PTP" aluminum foil printing and coating production line of Japan Donghai Metal Corporation, and introduced process technology testing equipment. China's machinery industry has also introduced pharmaceutical aluminum foil printing and coating production equipment in Jinzhou to carry out large-scale production with low speed control and large error. At that time, China's "PTP" production raw materials needed to be imported, with an annual output of about 420 tons, and most of them were "plain foil" with monochrome printing or no printing on the surface of aluminum foil. In the 1990s, China has been able to manufacture monochrome or multicolor aluminum foil printing and coating equipment, and can print color series of aluminum-plastic products for drug packaging. Moreover, the "PTP" aluminum foil material, aluminum foil printing ink, aluminum foil protective agent, adhesive, PVC plastic hard sheet and other materials used in blister packaging have been localized, and can meet the needs of the domestic pharmaceutical market. China has obtained the production license of pharmaceutical packaging materials, and 165 blister packaging material manufacturers, including sheet, film, aluminum foil (composite) enterprises, have a considerable production scale, Since blister packaging is one of the most widely used and fastest-growing flexible packaging materials in the pharmaceutical industry today, and it is also the main packaging form of solid pharmaceutical dosage forms in China at present, it has taken China nearly 20 years from the initial introduction of equipment, technology and raw materials to the self-sufficiency of its own manufacturing equipment and raw materials. It is expected that by 2010, China's pharmaceutical blister packaging will have a faster development

overview of materials for drug blister packaging

aluminum foil for drug blister packaging: "PTP" aluminum foil surface is composed of protective layer/printing layer/aluminum foil layer/printing layer/adhesive layer, and the most basic composition must include protective layer, aluminum foil layer and adhesive layer. The covering materials used for blisters are basically aluminum foil. The production of aluminum foil can be completed only through the joint operation of aluminum foil printing machine, coating machine, Slitter, packaging machine and other equipment

the aluminum foil processed in the pharmaceutical packaging material industry is customarily called "raw aluminum foil" or "raw foil". The raw foil is made of electrolytic aluminum with a purity of more than 99% by calendering. Aluminum has the advantages of rich resources, low price and easy processing. When used as drug packaging materials, aluminum foil is the only metal material in the packaging materials. Aluminum foil is non-toxic, tasteless, has excellent conductivity and shading, has extremely high moisture resistance, gas resistance and flavor retention, and can most effectively protect the packaged drugs. It is a packaging material that has not been replaced so far. No matter what kind of evaporated metal film or coated special film, it can not completely replace aluminum foil. In the field of modern packaging and decoration, almost all composite flexible packaging materials that need light tight or high barrier use aluminum foil as barrier layer. Because aluminum foil has the above advantages, light weight, certain strength and good printability, it can print various words or patterns on it. When it is made into blister packaging, it can be crushed with a little pressure during use. It is convenient for patients to take medicine and carry it. It is widely used in the packaging of solid dosage forms of drugs and has great development potential

medicinal aluminum foil coating protective agent and adhesive

after the printing of medicinal aluminum foil, it is necessary to coat a layer of protective agent on the surface of aluminum foil and adhesive on the other side. The purpose of coating protective agent on the surface of aluminum foil is to prevent the abrasion of the printing ink layer on the surface of aluminum foil, and also to prevent the drugs from being polluted during packaging due to the contact between the outer ink and the inner adhesive during the winding process of mechanical operation

the function of coating the adhesive layer is to make the aluminum foil stick to the plastic hard sheet after heat sealing, so that the medicine can be sealed. Most of the protective agents used now are solvent-based, and their main chemical components are: nitrocellulose, synthetic resin, plasticizer, cosolvent, diluent, etc. These components are mixed in a certain proportion, stirred in a reactor to form a solvent, and mechanically coated on the surface of aluminum foil to produce a protective film. The specific requirements for medicinal aluminum foil protectants are: good coating adhesion and flexibility with aluminum foil, good transparency and gloss, good volatility of heat-resistant solvent, no residual odor, no falling off of protective ink layer, and high wear resistance

the current application of medical aluminum foil adhesives. In the early days, pressure-sensitive adhesives, or single component adhesives, were used as adhesives. The main components were natural rubber or synthetic rubber. They could also be made of nitrocellulose fiber, acrylic resin and solvent. Because the main agent is polymer elastomer, plus tackifier as auxiliary agent, it can be stirred and reacted in organic solvent reactor to make it mixed into lotion, which has adhesion property with plastic rigid PVC. At present, polyurethane adhesive is mostly used to replace pressure-sensitive adhesive for aluminum foil of drug blister packaging

for blister packaging of drugs, complex data analysis can be carried out. Another material is PVC plastic sheet: PVC, also known as PVC, is the main resin formed by polymerization of vinyl chloride monomer, supplemented with auxiliary materials, such as plasticizer, heat stabilizer and lubricant, which is produced by extrusion or calendering. At present, almost all PVC used for blister packaging is produced by calendering, and PVC films used for composite materials are mostly produced by extrusion. Plastic materials for blisters also include pvc/pvdc (polyvinylidene chloride) composite sheet, pet (polyester), PE (polyethylene), PP (polypropylene) and other materials

Application of mechanized blister packaging equipment for drugs

aluminum foil material for blister packaging, after printing, coating and processing, together with polyvinyl chloride (PVC) plastic hard pieces, can fill drugs on special blister packaging equipment. Generally, pharmaceutical enterprises have several or dozens of blister packaging machines according to their own production capacity. Judging from the blister packaging equipment currently used, The following three types of blister packaging equipment are widely used

roller blister packaging machine

drug loading process and working principle of blister packaging machine: the formed plastic hard sheet PVC is heated and softened to a plastic state by the heating device. After the blister is sucked out by vacuum negative pressure on the roller forming mold roll, the filling device will fill the package into the blister, and then the covering aluminum foil coated with adhesive on one side is sealed on the blister by the roller thermal sealing device at a suitable temperature and pressure, Seal the package in the blister, mark the batch number and press out the break line on the set position by the typing and embossing device, and finally cut it into a certain size of packaging plate. That is: unwinding the formed plastic sheet → heating → Blister molding → material filling → sealing and covering the aluminum foil → marking the batch number → pressing the fracture line → feeding → punching → waste collection

cover packaging machine features: the structural form of the forming device is roller type, and the forming method is blister forming (negative pressure forming). The heated and softened plastic sheet is sucked into the cavity of the forming mold by vacuum to form a certain geometric shape to complete the blister forming. The forming pressure is less than lmpa, the size of the forming blister is small, and the forming depth is generally within 12mm; The blister packaging shape is simple, the blister stretching is uneven, the top is thin, and the plate is slightly bent. The structure of the sealing device is roller type, that is, the material to be sealed is continuously sealed between the two rotating rollers, and the line contacts, so the sealing pressure is large, and the sealing quality is easy to ensure. Because the negative pressure molding is adopted, the molding speed is limited, so that the utilization of the above thermal insulation plastic building materials in the buildings of the United States, Japan and other countries has been 10 minutes mature, and the production capacity is general, and the punching and cutting times are within 45 times/minute. Due to roll forming, roll sealing and roll feeding, the blister belt will bend around the roll surface during operation, so it is not suitable for forming large, deep and complex blisters, and the volume of packaged items should also be small

flat type blister packaging machine

operation process and working procedure of flat type blister packaging machine: the formed plastic sheet is heated at the flat type preheating device to a softened plastic state, which is pulled by the stepping device and sent to the flat type forming device. The softened plastic hard sheet is blown (or stamped and blown) into a blister with compressed air. The filling device fills the blister with the packaged material, and then transfers it to the flat type sealing device, Under the appropriate temperature and pressure, seal the covering plastic hard sheet with aluminum foil, and finally send it to the typing, stamping and punching device, print the batch number, press out the broken line, and punch it into plates of the specified size. That is: roll out the formed plastic hard piece → preheat → blow molding → material filling → seal and cover the aluminum foil → print the batch number → press and break the line → step → punching and cutting → waste collection. In recent years, some drugs need to be packaged away from light. A new packaging substrate, composite aluminum foil, has emerged. It does not need preheating and compressed air during molding, but is formed by mechanical stretching

usage features: the structural form of the forming device is flat plate type, and the forming method is blow molding (positive pressure molding). The heated and softened formed plastic hard sheet is blown into the cavity of the forming mold (or blow molding and stamping) with compressed air to form a blister with the required geometric shape. Due to the positive pressure molding, the molding quality is good, the dimensional accuracy is high, the reproducibility of small parts is good, the gloss and transparency are good, the blister is beautiful and straight, the wall thickness is uniform, the size of the molded blister can be larger, the stretching ratio can be larger, the maximum molding depth of the blister can be more than 35 mm, and the blister with complex shape can be molded, and the molding pressure is greater than 4MPa. The structure of the sealing device is flat plate type. The material aluminum foil to be sealed is sent between the flat plate sealing plates and then sealed by pressure. After a certain time, it leaves quickly. It belongs to intermittent sealing and surface contact. The total sealing pressure required is large and the precision of the sealing mechanism is high. Due to the use of plate forming and plate sealing, it has strong adaptability to the change of plate size, the plate arrangement is flexible, and the punched plates are flat and not warped. However, the sealing time is relatively long, which reduces the speed of the whole machine. Generally, the punching times are less than 35 times/min. The filling space of this type of machine is large, and multiple filling machines can be arranged at the same time, which makes it easier to pack multiple drugs in one plate, expands the packaging scope and improves the packaging grade

roller plate blister packaging equipment

roller plate blister packaging machine is derived from roller and plate blister packaging machines. Its operation process and working state are basically the same as the above two packaging machines. Its main features are: the structure of the heating device is plate structure, and the molding method is blow molding